Memphis is a city in the southwest corner of Tennessee, and the county seat of Shelby County. Memphis rises above the Mississippi River on the 4th Chickasaw Bluff just below the mouth of the Wolf River. As of 2006, Memphis had an estimated population of 670,902, making it the largest city in the state of Tennessee, the second largest in the southeastern region (only to Jacksonville, Florida), and the 17th largest in the United States. The greater Memphis metropolitan area area, including the adjacent areas of Mississippi and Arkansas, has a population of 1,260,581. This makes Memphis the second largest metropolitan area in Tennessee, surpassed only by metropolitan Nashville. Memphis is the youngest of Tennessee's four major cities (traditionally including Knoxville, Chattanooga, and Nashville). A resident of Memphis is referred to as a Memphian and the Memphis region is known as the Mid-South.